Have Questions? Email support@soracilabs.com
Klow: What Is Actually in the Four-Peptide Blend
GHK-Cu, BPC-157, TB-500 and KPV in one vial — and the copper peptide is roughly two thirds of it by mass.
In short
The Klow peptide blend is four compounds in one vial: GHK-Cu, BPC-157, TB-500 and KPV. The certificate of analysis puts GHK-Cu at roughly 63 per cent of the peptide mass, so this is not four equal parts. It is a copper-peptide preparation with three smaller additions, and reading it any other way will mislead your arithmetic.
What is in the Klow peptide blend
The name is an initialism of its components. The certificate of analysis for lot KLO8000126, issued by Vanguard Laboratory, lists the compound as BPC-157 / GHK-Cu / TB-500 / KPV and reports chromatographic purity above 99.5 per cent by HPLC-UV/VIS.
The same document quantifies each component individually: GHK-Cu at 62.80mg, BPC-157 at 13.50mg, KPV at 12.40mg and TB-500 at 10.50mg. In proportion that is roughly 63, 14, 12 and 11 per cent.
Consequently the first thing to understand about this preparation is that it is dominated by one component. Three of the four are present at around a sixth of the copper peptide.
GHK-Cu: most of the vial
GHK-Cu is a copper-binding tripeptide, and the copper is part of the molecule rather than an additive. That distinction matters enough that we wrote a separate guide on the coordination chemistry.
It also explains why the blend has a blue tint. The colour comes from the copper complex, and it is diagnostic: a GHK-Cu preparation that is not blue is telling you something.
Because GHK-Cu is nearly two thirds of the mass here, the blend inherits its handling requirements more than anyone else’s.
BPC-157 and TB-500: the pairing that already exists on its own
These two are routinely studied together, to the point that Soraci sells them as a separate two-compound product. BPC-157 is a fifteen-residue sequence derived from a protein found in gastric juice; TB-500 is a short fragment of thymosin beta 4 rather than the full 43-residue protein.
That fragment distinction trips people up regularly, which is why it has its own guide. For BPC-157 specifically, the research guide covers what the literature actually studies and how to read it honestly.
KPV: the component with no guide of its own
KPV is a tripeptide, lysine-proline-valine, and it is the C-terminal fragment of alpha-melanocyte-stimulating hormone. Those three residues are positions 11 to 13 of the parent hormone.
What makes it interesting is what it leaves behind. The published work characterises KPV as retaining the anti-inflammatory activity associated with alpha-MSH while lacking the pigmentary effects that come from melanocortin receptor engagement.
It is also unusually small, which has practical consequences: tripeptides can use peptide transporters that larger sequences cannot, and some of the intestinal work on KPV turns on exactly that.
Why the Klow peptide blend is weighted the way it is
A blend ratio is not an attempt at balance. Compounds differ in potency, in molecular weight and in the concentrations their respective literatures use, so equal masses would be arbitrary rather than neutral.
Still, the weighting is worth knowing before you calculate anything. If you treat an 80mg vial as four 20mg components you will be wrong about every one of them.
Our concentration calculation guide covers the arithmetic, and the molecular weight guide covers why equal masses of different peptides are not equal molar amounts.
Reading the certificate of analysis
The chromatogram for this lot resolves each component as a separate labelled peak, with GHK-Cu eluting first and BPC-157 and TB4 later in the run. Four peaks, four compounds, one injection.
That is the useful property of a blend COA. It does not only tell you purity; it tells you the preparation actually contains what the label claims, in what proportion, by a method that separates them.
Current certificates are published on the COA page. Lot numbers change, so the figures above describe the lot named rather than every vial ever produced.
Handling a four-peptide blend
One vial, one reconstitution, one set of storage conditions — and the most fragile component sets the limit. Handle the blend as you would handle its least stable member rather than its most robust.
Reconstitute gently with bacteriostatic water down the vial wall, keep it cold and dark, and avoid repeated freeze-thaw. The storage and stability guide covers which bonds fail first, and the solubility guide covers what to do if anything refuses to dissolve.
Klow peptide blend: frequently asked questions
What does Klow contain?
Four peptides: GHK-Cu, BPC-157, TB-500 and KPV. The certificate of analysis for lot KLO8000126 reports them at 62.80mg, 13.50mg, 10.50mg and 12.40mg respectively, with chromatographic purity above 99.5 per cent.
Are the four components present in equal amounts?
No, and this is the most common misreading. GHK-Cu is roughly 63 per cent of the peptide mass. The other three sit between 11 and 14 per cent each, so treating the vial as four equal parts will throw out every calculation downstream.
What is KPV?
A tripeptide of lysine, proline and valine, corresponding to residues 11 to 13 of alpha-melanocyte-stimulating hormone. Published work characterises it as retaining the anti-inflammatory profile associated with the parent hormone without the pigmentary effects mediated by melanocortin receptors.
Why is the solution blue?
Because of GHK-Cu. The colour comes from the copper coordination complex rather than a dye, and its absence in a GHK-Cu preparation is a meaningful signal rather than a cosmetic one.
Can I buy the components separately?
Some of them. GHK-Cu, BPC-157 and TB-500 are each sold individually, and BPC-157 with TB-500 is also sold as a two-compound product. KPV is currently only available within this blend.
Does a blend need different handling from a single peptide?
It needs the strictest handling of any component in it. One vial means one set of conditions, so the least stable member governs storage, reconstitution and how long a working solution stays usable.
Related products
Klow 80mg. The components sold separately: GHK-Cu, BPC-157 10mg, TB-500 10mg and the Wolverine BPC-157 + TB-500 pairing. Reconstitute with Hospira Bacteriostatic Water 30ml.
References
The sources below are indexed on PubMed, and compound records are held at PubChem.
- Dalmasso G, Charrier-Hisamuddin L, Nguyen HTT, Yan Y, Sitaraman S, Merlin D. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology — on KPV transport and activity.
- Brzoska T, Luger TA, Maaser C, Abels C, Böhm M. Alpha-melanocyte-stimulating hormone and related tripeptides. Endocrine Reviews — on the C-terminal tripeptide and its separation from pigmentary signalling.
- Pickart L, Margolina A. Regenerative and protective actions of the GHK-Cu peptide. International Journal of Molecular Sciences — on the copper complex that dominates this blend by mass.
Research use only. Every product referenced here is sold strictly for in-vitro laboratory research. Nothing on this page is medical advice, and none of these compounds are approved for human or veterinary use, diagnosis or treatment.
[…] BPC-157 also appears inside a four-compound preparation. For what else is in that vial and in what proportion, see our guide to the Klow peptide blend. […]