5-Amino-1MQ is a small-molecule research compound studied primarily as an inhibitor of nicotinamide N-methyltransferase (NNMT). It is investigated in experimental models involving cellular metabolism, NAD-related pathways, and energy regulation.
NNMT Research
Studied for its inhibition of nicotinamide N-methyltransferase and the downstream pathways associated with NNMT activity.
Cellular Metabolism
Investigated in experimental models examining cellular metabolism and metabolic regulation.
NAD-Related Pathways
Used in laboratory research exploring NNMT-associated nicotinamide metabolism and NAD-related biochemical pathways.
Energy Regulation Research
Investigated in preclinical research involving cellular energy balance and metabolic signaling mechanisms.
Not a peptide
5-Amino-1MQ is 5-amino-1-methylquinolinium — a small, permanently charged aromatic heterocycle. It has no amide backbone and no amino-acid sequence, so peptide handling intuitions and molecular-weight corrections do not apply to it.
It is a membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme that methylates nicotinamide using SAM as the methyl donor. That single reaction sits at a junction: it removes nicotinamide from the NAD+ salvage pathway and consumes a methyl group at the same time.
Handling differs from the rest of the catalogue
Because it is a small charged molecule rather than a protein, the usual peptide anxieties — aggregation, surface adsorption, freeze-thaw damage — are far less relevant. Keep it cold and dark, and protect solutions from light.
The arithmetic is also simpler: a defined small molecule has a single molecular weight and a stated purity, with no salt form or net peptide content correction to apply.
Storage
Sealed and lyophilised: refrigerated, protected from light. In solution: refrigerated, and treat time at room temperature as a cost. Avoid repeated freeze-thaw once reconstituted.
What ships, and what is on the certificate
The vial ships sealed as it was filled. Every compound in the catalogue is tested by an outside laboratory — Vanguard Laboratory in Olympia, Washington — and the certificate is published in full rather than summarised.
The certificate reports chromatographic purity by HPLC with the chromatogram visible, the measured quantity in milligrams, and an endotoxin result by LAL. Measured quantity usually reads slightly above the label, which is normal: fills are targeted high so every vial meets its stated content.
Frequently asked questions
Is 5-Amino-1MQ a peptide?
No. It is a quinolinium small molecule with no amide backbone and no sequence.
What does it inhibit?
Nicotinamide N-methyltransferase, which methylates nicotinamide using SAM, producing 1-methylnicotinamide and SAH.
How does that relate to NAD+?
Nicotinamide is the substrate of the NAD+ salvage pathway. Methylating it removes it from that pathway, so NNMT activity competes with NAD+ regeneration.
Does it come with a certificate of analysis?
Yes. Every compound is tested by an independent laboratory and the full certificate, chromatogram included, is published on the site rather than summarised.
Is this a medicine?
No. It is sold for in-vitro laboratory research use only. It is not a drug, supplement or cosmetic, and is not for human or veterinary use.
Reviews
There are no reviews yet.