Kisspeptin is a naturally occurring peptide studied for its role in reproductive hormone signaling, GnRH activation, and neuroendocrine regulation. Supplied for qualified in-vitro and ex-vivo research only.
Reproductive Signaling
Studied for its role in regulating reproductive hormone signaling pathways.
GnRH Pathway Research
Investigated as an important upstream regulator of gonadotropin-releasing hormone signaling.
LH & FSH Signaling
Researched for its relationship with luteinizing hormone and follicle-stimulating hormone pathways.
Endocrine Research
Used in research exploring reproductive and neuroendocrine signaling mechanisms.
What kisspeptin is
Kisspeptin has one of the better origin stories in this field. It was first identified as a metastasis suppressor — the gene was named KISS1 after the town where it was discovered — and only later turned out to be the upstream trigger for the reproductive axis.
It signals through the receptor known as KISS1R or GPR54, and its role sits above GnRH: kisspeptin neurons drive GnRH release rather than acting on the pituitary directly. That places it a step further upstream than most compounds studied in this axis.
Handling and reconstituting kisspeptin
Standard lyophilised peptide handling applies. Keep the sealed vial cold and dark until it is used. Reconstitute by running bacteriostatic water slowly down the inside wall of the vial rather than firing it onto the powder cake, and let it dissolve without shaking — swirl gently if it needs help.
The concentration you end up with is set by how much water you add, not by the vial size. Our reconstitution calculator turns vial mass and water volume into a concentration and a syringe reading.
Storage
Sealed and lyophilised: refrigerated, protected from light. In solution: refrigerated, and treat time at room temperature as a cost. Avoid repeated freeze-thaw once reconstituted.
What ships, and what is on the certificate
The vial ships sealed as it was filled. Every compound in the catalogue is tested by an outside laboratory — Vanguard Laboratory in Olympia, Washington — and the certificate is published in full rather than summarised.
The certificate reports chromatographic purity by HPLC with the chromatogram visible, the measured quantity in milligrams, and an endotoxin result by LAL. Measured quantity usually reads slightly above the label, which is normal: fills are targeted high so every vial meets its stated content.
Frequently asked questions
Why is it called kisspeptin?
The gene KISS1 was named after Hershey, Pennsylvania, where it was identified as a metastasis suppressor. The reproductive role was discovered later.
What receptor does it act on?
KISS1R, also known as GPR54. Kisspeptin neurons drive GnRH release, placing it upstream of the classical reproductive axis.
How should it be reconstituted?
Add bacteriostatic water slowly down the inside wall of the vial, then let it dissolve without shaking. The reconstitution calculator will convert vial mass and water volume into a concentration and a syringe reading.
Does it come with a certificate of analysis?
Yes. Every compound is tested by an independent laboratory and the full certificate, chromatogram included, is published on the site rather than summarised.
Is this a medicine?
No. It is sold for in-vitro laboratory research use only. It is not a drug, supplement or cosmetic, and is not for human or veterinary use.
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