MOTS-C is a mitochondrial-derived peptide studied for its involvement in cellular metabolism, metabolic signaling, and responses to energetic stress. It is of particular research interest because it is encoded within mitochondrial DNA.
Mitochondrial Research
Studied as a mitochondrial-derived signaling peptide and for its relationship with mitochondrial function.
Cellular Metabolism
Investigated in experimental models examining cellular metabolism and metabolic regulation.
Energy Pathways
Researched for its involvement in cellular energy sensing and responses to metabolic stress.
Metabolic Signaling
Used in laboratory studies exploring signaling pathways associated with metabolic homeostasis and cellular adaptation.
What MOTS-c is
MOTS-c is unusual in this catalogue because of where its gene sits: it is encoded in mitochondrial DNA rather than in the nucleus. That makes it one of a small group of mitochondrial-derived peptides, and the reason it is studied alongside NAD+ and SS-31 despite working nothing like either.
Grouping compounds by the organelle they are associated with is convenient but misleading. NAD+ is a redox cofactor, SS-31 binds a structural lipid, and MOTS-c is a peptide product of the mitochondrial genome. Three genuinely different objects.
Handling and reconstitution
Standard lyophilised peptide handling applies. Keep the sealed vial cold and dark until it is used. Reconstitute by running bacteriostatic water slowly down the inside wall of the vial rather than firing it onto the powder cake, and let it dissolve without shaking — swirl gently if it needs help.
The concentration you end up with is set by how much water you add, not by the vial size. Our reconstitution calculator turns vial mass and water volume into a concentration and a syringe reading.
Storage
Sealed and lyophilised: refrigerated, protected from light. In solution: refrigerated, and treat time at room temperature as a cost. Avoid repeated freeze-thaw once reconstituted.
What ships, and what is on the certificate
The vial ships sealed as it was filled. Every compound in the catalogue is tested by an outside laboratory — Vanguard Laboratory in Olympia, Washington — and the certificate is published in full rather than summarised.
The certificate reports chromatographic purity by HPLC with the chromatogram visible, the measured quantity in milligrams, and an endotoxin result by LAL. Measured quantity usually reads slightly above the label, which is normal: fills are targeted high so every vial meets its stated content.
Frequently asked questions
Why is MOTS-c called mitochondrial-derived?
Because its gene is encoded in mitochondrial DNA rather than in the nucleus, which is unusual for a peptide.
Is it similar to NAD+ or SS-31?
Only in being studied in a mitochondrial context. NAD+ is a redox cofactor and SS-31 binds cardiolipin, a structural lipid. The three work by entirely different means.
How should it be reconstituted?
Add bacteriostatic water slowly down the inside wall of the vial, then let it dissolve without shaking. The reconstitution calculator will convert vial mass and water volume into a concentration and a syringe reading.
Does it come with a certificate of analysis?
Yes. Every compound is tested by an independent laboratory and the full certificate, chromatogram included, is published on the site rather than summarised.
Is this a medicine?
No. It is sold for in-vitro laboratory research use only. It is not a drug, supplement or cosmetic, and is not for human or veterinary use.
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