DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring neuropeptide studied in experimental models involving sleep regulation, neurological signaling, stress-response pathways, and neuroendocrine activity.
Sleep Regulation Research
Investigated in experimental models examining sleep-related processes and biological sleep regulation.
Neurological Signaling
Studied for its potential involvement in signaling pathways within the central nervous system.
Stress-Response Research
Researched in experimental systems exploring physiological stress responses and regulatory mechanisms.
Neuroendocrine Research
Used in laboratory research examining interactions between neurological and endocrine signaling pathways.
What DSIP is, honestly
DSIP is a nine-residue peptide — Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu — isolated in 1974 from the cerebral venous blood of rabbits driven into slow-wave sleep, and sequenced in 1978.
Half a century later it still has no identified receptor, no confirmed precursor protein and no identified gene even in the animal it came from. Its in-vitro half-life is around fifteen minutes. The name records the experiment that found it, not a confirmed mechanism, and the sleep literature remains genuinely mixed.
That makes it an interesting unresolved question rather than a settled tool, and it is worth knowing that before choosing it for work.
Handling and reconstitution
Standard lyophilised peptide handling applies. Keep the sealed vial cold and dark until it is used. Reconstitute by running bacteriostatic water slowly down the inside wall of the vial rather than firing it onto the powder cake, and let it dissolve without shaking — swirl gently if it needs help.
The concentration you end up with is set by how much water you add, not by the vial size. Our reconstitution calculator turns vial mass and water volume into a concentration and a syringe reading.
Storage
Sealed and lyophilised: refrigerated, protected from light. In solution: refrigerated, and treat time at room temperature as a cost. Avoid repeated freeze-thaw once reconstituted.
What ships, and what is on the certificate
The vial ships sealed as it was filled. Every compound in the catalogue is tested by an outside laboratory — Vanguard Laboratory in Olympia, Washington — and the certificate is published in full rather than summarised.
The certificate reports chromatographic purity by HPLC with the chromatogram visible, the measured quantity in milligrams, and an endotoxin result by LAL. Measured quantity usually reads slightly above the label, which is normal: fills are targeted high so every vial meets its stated content.
Frequently asked questions
What is the DSIP sequence?
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, a nonapeptide of roughly 850 daltons.
Does DSIP have a known receptor?
No. None has been cloned, and no gene or precursor has been confirmed even in the rabbit it was isolated from.
Is the sleep evidence settled?
No. Some studies report increased slow-wave sleep and reduced REM; others find no correlation at all.
How should it be reconstituted?
Add bacteriostatic water slowly down the inside wall of the vial, then let it dissolve without shaking. The reconstitution calculator will convert vial mass and water volume into a concentration and a syringe reading.
Does it come with a certificate of analysis?
Yes. Every compound is tested by an independent laboratory and the full certificate, chromatogram included, is published on the site rather than summarised.
Is this a medicine?
No. It is sold for in-vitro laboratory research use only. It is not a drug, supplement or cosmetic, and is not for human or veterinary use.
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